2 citations
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January 1993 This study found that human trichohyalin has a unique protein sequence potentially contributing to at least three important functions in hair follicle and epidermal cells.
January 2013 in “Shanghai Textile Science & Technology” This study found that milk protein grafting and cross-linking treatment significantly improved the pilling resistance of rabbit hair knitted fabric.
13 citations
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January 2018 in “Advances in experimental medicine and biology” 11 citations
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September 1996 in “Journal of applied polymer science” In this study, treatment with aqueous KCN selectively converted disulfide bonds to monosulfide crosslinks in hair, leading to changes in microstructural properties and rubberlike elasticity under specific laboratory conditions.
2 citations
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September 1996 in “Journal of Applied Polymer Science” This study found that treating hair with aqueous KCN converts disulfide bonds to monosulfide crosslinks, affecting the elasticity and crosslink distribution in hair microstructures.
38 citations
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June 2005 in “Matrix Biology” Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
3 citations
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June 2023 in “ACS sustainable chemistry & engineering” In this study, a method using riboflavin phosphate, citric acid, and polyols successfully optimized protein cross-linking in hair of all colors through visible light-mediated photo-cross-linking, improving the mechanical properties and hair-setting effects without the influence of hair color.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that a novel bioengineered microneedle patch successfully delivered minoxidil to induce hair growth in a mouse model, suggesting a promising approach to improve treatment for androgenetic alopecia.
April 2025 in “Pharmaceuticals” This study found that novel thiol-reactive cross-linking agents, particularly APA, significantly improved the tensile strength and elasticity of human hair fibers by effectively regenerating disulfide bridges, with potential applications for advanced hair repair treatments in the cosmetic industry.
61 citations
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January 2013 in “International Journal of Biological Macromolecules” This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.
4 citations
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June 2022 in “Journal of cleaner production” This study found that a new eco-friendly hair crosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.
January 2026 in “RSC Advances” The hydrogel helps heal wounds without scars by releasing two drugs gradually.
August 2024 in “Nature Communications” This study found that in female mice, softer, lightly crosslinked gelatin-based hydrogels promoted better wound healing with less scarring and inflammation compared to stiffer, heavily crosslinked hydrogels, affecting immune and stromal cell behavior.
This study found that a bio-based repair solution containing hydrolysed wool keratin, serine, and transglutaminase improved the physical and chemical properties of damaged hair, increasing its strength, flexibility, and thermal stability while offering long-lasting protection against chemical damage.
57 citations
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July 1983 in “Journal of Investigative Dermatology” 44 citations
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January 1984 in “Molecular and Cellular Biochemistry” 7 citations
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May 2024 in “Gels” This study evaluated a new collagen and tannic acid hydrogel in rat liver and heart bleeding models, finding it reduced blood loss and hemostatic time compared to commercial products, with benefits such as enhanced biodegradability and potential for clinical use.
6 citations
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October 1988 in “Clinics in Dermatology” This article reviews gaps in our understanding of molecular events in hair follicle growth, focusing on keratin synthesis and protein oxidation, but reports no new findings.
3 citations
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January 1984 December 2024 in “Macromolecular Bioscience” This study reports that a novel UV-based crosslinking process for collagen sponges significantly decreases crosslinking time compared to traditional methods, and supports effective cell proliferation and wound regeneration in a mouse model, without causing abnormal angiogenic or immune responses.
44 citations
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March 2019 in “Experimental Dermatology” This study analyzed the cornified envelope of epidermal proteins, finding keratins dominate, which may help explain the minimal impact of deleting genes for single envelope components in congenital ichthyosis.
June 2025 in “ACS Biomaterials Science & Engineering” In this study, researchers developed a new microneedle patch delivery system for minoxidil, which enhanced its controlled release and improved hair growth in mice, potentially offering better treatment outcomes for androgenetic alopecia.
1 citations
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January 1984 
December 2025 in “Cosmetics” In a laboratory study, researchers found that a novel Bioactive Crosslink Repair Complex improved both the protection and repair of chemically damaged hair, enhancing tensile strength, shine, and cuticle alignment when added to bleaching mixtures and leave-in conditioners.
54 citations
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January 1984 in “Molecular and Cellular Biochemistry” September 2025 in “International Journal of Biological Macromolecules” In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.
161 citations
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June 1993 in “Journal of Biological Chemistry” This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.
15 citations
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February 1999 in “The anatomical record” This study found that defective cross-linking in hair cuticles is observable in a minority of mouse hair mutants, suggesting different proteins are involved in cross-linking across cell types.
February 1999 in “The anatomical record” This study observed defects in hair cuticle cross-linking in some, but not all, mouse mutants with sparse or structurally unsound hair.
In this study, researchers found that follicular and epidermal transglutaminases are biochemically and immunologically distinct, suggesting the possibility of selectively modifying hair or epidermal proteins.