Controlled Release of Minoxidil Through Hydrogel Cross-Linking to Treat Androgenetic Alopecia

This study presents a novel method to enhance the delivery of minoxidil for treating androgenetic alopecia by using hydrogel cross-linking. The researchers developed injectable hydrogels through the formation of Schiff bases between minoxidil and aldehyde-modified hyaluronic acid, allowing for a controlled release of minoxidil over 6 weeks in vitro. In vivo tests on a mouse model showed hair growth induction following intradermal injection. Additionally, the hydrogels were incorporated into microneedle patches, which provided precise and uniform delivery of minoxidil into the skin, demonstrating mechanical robustness and the ability to penetrate human skin. This approach shows promise in improving the efficacy and patient outcomes of minoxidil treatment for hair loss.