9 citations
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February 2014 in “Tissue Engineering and Regenerative Medicine” This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.
6 citations
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July 2012 in “Experimental Dermatology” In this study, treatment with human follicular keratinocyte-conditioned media improved the trichogenicity of cultured dermal cells by activating key signalling pathways, suggesting its potential use in cell therapy for hair loss.
5 citations
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December 2024 in “Bioengineering” In this study, conditioned medium from genetically engineered mesenchymal stem cells significantly improved wound healing, re-epithelialization, hair follicle formation, and angiogenesis in diabetic mice, suggesting a promising new approach for diabetic ulcer care.
5 citations
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November 2020 in “Cells” The researchers reported that using a concentrate of conditioned mesenchymal stem cells derived from the placenta accelerated wound healing and regeneration in laboratory animals with severe local radiation injuries.
5 citations
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September 2019 in “ACS Applied Bio Materials” This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.
3 citations
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January 2023 in “Physiological Research” This review suggests that mesenchymal stem cells' therapeutic effects might be due to bioactive substances they release, rather than the cells themselves, highlighting the potential of the MSC secretome as a novel, cell-free therapeutic approach.
2 citations
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May 2024 in “European journal of medical research” This study found that a conditioned medium from human umbilical cord mesenchymal stem cells cultured in a gelatin sponge significantly enhanced hair growth and promoted skin angiogenesis in a mouse model, more effectively than a monolayer culture.
2 citations
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November 2023 in “Laboratory Animal Research” In this study, the combination of conditioned medium from human adipose-derived stem cells and photobiomodulation significantly enhanced wound healing in type 2 diabetic rats compared to using either treatment alone, with particularly superior results in wound strength and new blood vessel formation.
2 citations
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May 2021 in “IOP Conference Series Earth and Environmental Science” This study found that treating SM-MSCs with 150 μg/mL IGF-1 led to the highest increases in growth factor proteins BMP-2, FGF-18, and TGF-β1 in their conditioned media.
1 citations
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February 2023 in “Journal of Cellular Biochemistry” In this study, conditioned media from stem cell-derived cardiomyocytes significantly reduced lung cancer cell viability and increased apoptosis compared to fibroblast conditioned media, suggesting its potential antitumor properties.
April 2026 in “Stem Cell Research & Therapy” This systematic review reports that regenerative medicine therapies, such as conditioned media, platelet-rich fibrin, and stem cells, show promising efficacy and safety in treating androgenetic alopecia, though heterogeneity in study protocols and limited long-term data emphasize the need for further research to optimize these strategies.
February 2026 in “Scientific Reports” This preclinical study found that Mesenchymal Stem Cell-derived Conditioned Media formulations were safe and effective in rat and mouse models for treating chemotherapy- and radiation-induced oral mucositis, demonstrating improved tissue regeneration and healing, most notably at higher concentrations.
February 2026 in “Human Cell” This study found that factors released by mesenchymal stromal cells can enhance the proliferation and migration of keratinocytes in vitro, which may contribute to improved understanding of their role in wound healing and potential applications in dermal regeneration therapies.
September 2025 in “Stem Cell Research & Therapy” This review suggests that extracellular vesicles and conditioned media might be safe and effective for skin rejuvenation and lightening, but further high-quality studies are needed to confirm these findings.
July 2025 in “Scientific Reports” This study found that dermal papilla cell-conditioned medium can protect against UV-induced skin aging in a mouse model by modulating ferroptosis pathways, highlighting its potential for treating oxidative stress-related skin conditions.
June 2025 in “Archives of Dermatological Research” This study found that photobiomodulation-irradiated conditioned medium from human adipose-derived stromal cells enhanced hair growth in mice, suggesting its potential as a treatment for hair loss by increasing growth factor secretion.
May 2025 in “Research Square (Research Square)” This study found that conditioned medium from photobiomodulation-irradiated adipose-derived stromal cells enhanced hair growth in a mouse model of hair loss more effectively than non-irradiated medium, suggesting potential for treating alopecia by boosting growth factor secretion.
March 2025 in “Regenerative Therapy” This study suggests that SACM may enhance hair growth more effectively than non-treated ACM, highlighting the potential of S. maxima as a promising agent for use in pharmaceutical and cosmeceutical industries.
January 2025 in “Antioxidants” In this study, repetitive subcutaneous administrations of a conditioned medium from stem cells significantly suppressed hair graying in mice exposed to X-ray irradiation, likely through antioxidative mechanisms involving HGF and potentially VEGF.
This study suggests that using cell-free dexamethasone-primed stem cell media may offer a promising alternative treatment for systemic lupus erythematosus, showing immunomodulatory benefits and therapeutic efficacy in reducing various complications.
November 2023 in “PubMed” In this study using animal models, umbilical cord stem cell conditioned media combined with oral anti-androgens improved hair regeneration in androgenetic alopecia, enhancing hair follicle cycles and reducing inflammation, suggesting potential as a promising therapy.
This study found that conditioned media derived from dental pulp stem cells improved hair growth in 75% of men with androgenic alopecia, with positive results observed regardless of disease severity or the use of a dihydrotestosterone inhibitor.
January 2023 in “Journal of Cosmetics, Dermatological Sciences and Applications” In this study, researchers assessed the efficacy of Trichosera® hair serum, containing mesenchymal stromal cells conditioned media, among 40 healthy Indian volunteers, finding significant improvements in hair growth rate, hair density, scalp condition, and reduction in hair fall without notable adverse effects.
The study found that conditioned medium from placental cells and sub-cultured placental tissue promoted angiogenesis in HUVECs, with early pregnancy cells showing more significant effects than those from full-term pregnancy.
This study found that conditioned medium from human placental cells or tissue promoted angiogenesis in HUVECs in vitro, with early-pregnancy placental cells and whole placental tissue showing more significant effects.
This study found that conditioned media from SHED stem cells cultured in STK2 media significantly stimulated hair growth in mice more effectively than media from HFSCs.
January 2010 in “Seoul National University Open Repository (Seoul National University)” This review discusses the growth factors produced by adipose tissue-derived stem cells that are associated with hair growth stimulation and reports no new clinical findings.
January 2013 in “프로그램북(구 초록집)” This study found that ADSC-conditioned media was effective in increasing hair density and thickness in female pattern hair loss patients over a 12-week period.
January 2009 in “Chinese Journal of Aesthetic Medicine” This study found that treatment with human dermal papilla cells conditioned medium resulted in an 81.25% total effective rate and a 62.50% cure rate for androgenetic alopecia.
5 citations
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May 2022 in “Fashion and Textiles” This study found that Argan oil conditioner significantly enhanced tensile strength and retained hair color in bleached hair more effectively than Camellia oil.