467 citations
,
October 2014 in “European Journal of Endocrinology” This paper reviews the diagnostic criteria, etiological factors, and treatment approaches for PCOS, highlighting the importance of considering metabolic issues such as insulin resistance and obesity, but reports no new findings.
55 citations
,
March 2000 in “American journal of clinical dermatology” Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.
52 citations
,
April 2008 in “Therapeutics and clinical risk management” This review covers the use of combined oral contraceptives, particularly drospirenone, for managing polycystic ovary syndrome and discusses related metabolic controversies without reporting new clinical results.
46 citations
,
January 2007 in “The European Journal of Contraception & Reproductive Health Care” This review discusses the increased risk of venous thromboembolism associated with combined hormonal contraceptives, particularly noting higher risks with certain progestins like desogestrel, gestodene, and cyproterone acetate, but reports no new clinical findings.
42 citations
,
July 2015 in “Journal of The American Academy of Dermatology” This review discusses diagnostic and treatment considerations for women with cutaneous hyperandrogenism, noting therapeutic options are more effective for hirsutism and acne than for androgenetic alopecia, but reports no new clinical results.
34 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This review discusses hormone-modulating therapies for androgen-mediated cutaneous disorders in women but reports no new clinical results and highlights the need for more rigorous studies.
31 citations
,
June 2015 in “British Journal of Dermatology” Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.
29 citations
,
March 2017 in “International Journal of Women's Dermatology” This review found that combined oral contraceptives and spironolactone are effective treatments for adult acne in women, but noted that oral contraceptives increase the risk of venous thromboembolism and require individual risk assessment before use.
22 citations
,
March 2018 in “American Journal of Clinical Dermatology” This study found that hormonal antiandrogen acne treatment is associated with shorter antibiotic durations in women, suggesting early initiation may reduce overall antibiotic use.
22 citations
,
January 2013 in “Journal of The American Academy of Dermatology” This review discusses the role of contraceptives in dermatology, particularly for acne treatment and managing patients on teratogens, but reports no new clinical results.
21 citations
,
July 2014 in “Clinics in Dermatology” This review examines the role of hormones in acne pathogenesis, the use of hormonal therapies for treatment, and the importance of contraceptive counseling during isotretinoin therapy, but reports no new clinical results.
11 citations
,
April 2017 in “The European Journal of Contraception & Reproductive Health Care” This review highlights that Cyproterone acetate combined with ethinylestradiol is highly effective for treating severe acne and hirsutism in women with hyperandrogenism, and it also provides benefits for cycle control and mood improvement, according to the analysis of 78 studies.
10 citations
,
January 2017 in “Expert Opinion on Pharmacotherapy” This review discusses the clinical features and treatment options for adult acne, highlighting the need for tailored management in specific populations, but reports no new findings.
9 citations
,
May 2015 in “Cardiology Clinics” This review discusses the timing and management of dyslipidemia screening around pregnancy and emphasizes dietary, exercise, and glycemic interventions during pregnancy without reporting new clinical outcomes.
8 citations
,
April 2022 in “Revista Brasileira Ginecologia e Obstetrícia” This review explores contraceptive options for women with polycystic ovary syndrome, emphasizing the need for tailored choices based on individual clinical, hormonal, and metabolic profiles, but reports no new clinical findings.
5 citations
,
May 2017 in “Current Opinion in Pediatrics” This review found that hormonal therapies, including FDA-approved combined oral contraceptive pills and spironolactone, are effective and well-tolerated treatments for acne vulgaris in adolescents with or without endocrine disorders, providing alternative options to antibiotics.
5 citations
,
April 2013 in “Current Problems in Pediatric and Adolescent Health Care” This review discusses the prevalence and management of polycystic ovary syndrome in women, particularly noting gaps in understanding its presence in adolescents, and reports no new clinical findings.
3 citations
,
July 2022 in “BJOG: An International Journal of Obstetrics and Gynaecology” This study reports that among young women, combined oral contraceptives containing chlormadinone, among others, are associated with an increased risk of venous thromboembolism compared to those containing levonorgestrel with low ethinylestradiol.
2 citations
,
April 2019 in “Медицинский совет” This article reviews the problem of acne and hirsutism in women, highlighting the effectiveness of combined oral contraceptives containing drospirenone and levomefolate calcium in managing these conditions and polycystic ovary syndrome, but no new clinical results are reported.
2 citations
,
July 2012 in “Journal of Pediatric and Adolescent Gynecology” This case report describes an obese young adolescent girl with PCOS who presented with high testosterone levels and severe hyperinsulinemia, successfully treated with continuous combined oral contraceptives.
1 citations
,
October 2010 in “Cambridge University Press eBooks” This review discusses strategies for managing dermatological symptoms of hyperandrogenism in PCOS by reducing androgen levels and actions, and reports no new clinical results.
November 2025 in “Contraception” This study suggests that using combined oral contraceptives does not increase hair glucocorticoid levels, but hair treatments should be considered as a confounder in stress biomarker assessments.
October 2025 in “Pielegniarstwo XXI wieku / Nursing in the 21st Century” This review discusses the effectiveness and mechanisms of combined oral contraceptives in treating acne vulgaris but reports no new clinical results; the authors highlight their antiandrogenic effects for managing acne and related endocrine disorders.
June 2025 in “Medicine theory and practice” This study compared the effectiveness of combined oral contraceptives and antiandrogens for treating women with polycystic ovarian syndrome in late reproductive age.
January 2025 in “Dermatology and Therapy” This review updates dermatologists on both FDA-approved and off-label hormonal therapies, including combined oral contraceptives, clascoterone, and spironolactone, used for acne treatment, providing insights into emerging approaches for managing the condition.
This study observed that women using combined oral contraceptives experienced more nausea, vomiting, and hair loss, while those on Depo-Provera were more likely to gain weight.
This paper addresses diagnostic criteria and treatment options for polycystic ovary syndrome, emphasizing lifestyle changes and combination oral contraceptives as primary management strategies, but it reports no new clinical results.
May 2019 in “Paediatrics and child health” This review discusses diagnosis and management strategies for polycystic ovary syndrome in teenagers and reports no new clinical findings, emphasizing tailored approaches considering symptoms, psychological well-being, and fertility needs.
March 2007 in “Journal of Obstetrics and Gynaecology Canada” This review discusses the diagnosis and treatment of hyperandrogenism in women, emphasizing that cyproterone acetate is effective for severe hirsutism, though it reports no new clinical findings.
This article reviews the effects of combined oral contraceptives on skin conditions and suggests prescribing guidelines for women with acne, as it reports no new clinical results.