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    Glossary Cochlear Hair Cells

    specialized inner ear cells that convert sound into signals

    Cochlear hair cells are specialized sensory cells located in the cochlea of the inner ear. They play a crucial role in hearing by converting sound vibrations into electrical signals that the brain can interpret. There are two types: inner hair cells, which primarily send auditory information to the brain, and outer hair cells, which amplify and fine-tune sound vibrations. Damage to these cells can lead to hearing loss.

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    Research 30 of 264

    1. Cochlea hair cell rescue after a noise-induced hearing loss using a low level laser therapy (LLLT) 2011
    2. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    3. Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea PloS one · 2012 · 71 citations
    4. Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx OPAL (Open@LaTrobe) (La Trobe University) · 2021
    5. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    6. The structural and functional aspects of hair cell regeneration in the chick as a result of exposure to intense sound Experimental Neurology · 1992 · 63 citations
    7. Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice British Journal of Pharmacology · 2025
    8. Aging Alters Hair Cell Physiological Properties in Mice with Late-Onset Age-Related Hearing Loss. bioRxiv (Cold Spring Harbor Laboratory) · 2025
    9. XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss Advanced Science · 2026
    10. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice Neurobiology of aging · 2008 · 62 citations
    11. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    12. Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice Biomedicine & Pharmacotherapy · 2025
    13. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    14. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo Neuroscience Letters · 2014 · 26 citations
    15. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    16. Molecular basis of hair cell loss 2015 · 66 citations
    17. Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss Molecular Medicine Reports · 2017 · 2 citations
    18. Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways Biochemical pharmacology · 2024
    19. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    20. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    21. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    22. Ototoxicity of Common Topical Antimycotic Preparations The Laryngoscope · 2000 · 65 citations
    23. Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects Research Square (Research Square) · 2021
    24. The role of cochlea extracellular matrix in age related hearing loss DOAJ (DOAJ: Directory of Open Access Journals) · 2025
    25. 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway Journal of Cellular and Molecular Medicine · 2024 · 1 citations
    26. Les nouvelles stratégies thérapeutiques du traumatisme sonore par bruit d'arme chez le cobaye HAL (Le Centre pour la Communication Scientifique Directe) · 2010
    27. Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice PLoS ONE · 2025
    28. Effect of low level laser therapy on hair cell regeneration following gentamicin induced ototoxicity in postnatal organotypic culture of rat cochlea Proceedings of SPIE · 2010 · 1 citations
    29. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea Research Square (Research Square) · 2022
    30. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations