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    Glossary Cell Fate

    process determining cell's specialized function or type

    Cell fate refers to the final specialized function or type that a cell is destined to become during development. This process is influenced by various signals and environmental factors that guide the cell to differentiate into specific cell types, such as skin cells, nerve cells, or hair follicle cells. Understanding cell fate is crucial for fields like regenerative medicine and developmental biology, as it helps in manipulating cells for therapeutic purposes.

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    1. Cell fate decisions: emerging roles for metabolic signals and cell morphology EMBO Reports · 2017 · 100 citations
    2. Mouse notch: expression in hair follicles correlates with cell fate determination. 1993 · 150 citations
    3. Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · 2017 · 3 citations
    4. Spatiotemporal Switches in Progenitor Cell Fate Govern Upper Hair Follicle Growth and Maintenance Journal of Investigative Dermatology · 2025 · 2 citations
    5. Multi-scale modeling for cell fate specification during regeneration and development eScholarship (California Digital Library) · 2020
    6. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate 2023 · 1 citations
    7. The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate Trends in cell biology · 2018 · 33 citations
    8. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    9. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    10. <i>N</i>1-acetylspermidine is a determinant of hair follicle stem cell fate Journal of Cell Science · 2021 · 17 citations
    11. Epidermal stem cell fate: what can we learn from embryonic stem cells? 2007 · 15 citations
    12. Fibronectin meshwork controls epithelial stem cell fate bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    13. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    14. Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture Nature cell biology · 2024 · 2 citations
    15. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    16. The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Cell Metabolism · 2025
    17. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    18. Editorial: Directing Stem Cell Fate Using Plant Extracts and Their Bioactive Compounds Frontiers in Cell and Developmental Biology · 2022 · 4 citations
    19. The role of translation in keratinocyte cell fate determination. Apollo (University of Cambridge) · 2018
    20. 1349 Inducing fate changes at the hair follicle stem cell nice Journal of Investigative Dermatology · 2023
    21. From structural resilience to cell specification — Intermediate filaments as regulators of cell fate ˜The œFASEB journal · 2020 · 9 citations
    22. A probabilistic Boolean model on hair follicle cell fate regulation by TGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math> Biophysical Journal · 2022 · 5 citations
    23. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling npj Regenerative Medicine · 2022 · 3 citations
    24. Developmental Mechanisms Controlling Cell Fate, Evolution of Elsevier eBooks · 2016
    25. Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis Genes & development · 2010 · 95 citations
    26. Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway Stem cells · 2013 · 73 citations
    27. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    28. Neuregulin3 alters cell fate in the epidermis and mammary gland BMC developmental biology · 2007 · 39 citations
    29. Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate Genes · 2019 · 28 citations
    30. Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa Journal of the European Academy of Dermatology and Venereology · 2025