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    Glossary cAMP response element-binding protein

    regulates gene transcription in response to cellular signals

    cAMP response element-binding protein (CREB) is a cellular protein that binds to specific DNA sequences called cAMP response elements, thereby regulating the transcription of certain genes. It plays a crucial role in various cellular processes, including the growth and survival of cells, by responding to hormonal signals and other external stimuli.

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    1. 126 cAMP response element-binding protein 1 (CREB) is a β-catenin-regulated transcription factor in squamous cell carcinoma (SCC) cells Journal of Investigative Dermatology · 2018
    2. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    3. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport Journal of ethnopharmacology · 2023
    4. 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium Journal of Investigative Dermatology · 2017
    5. Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein Small ruminant research · 2019 · 1 citations
    6. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    7. Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin PLoS ONE · 2014 · 62 citations
    8. Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002 · 277 citations
    9. Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy Journal of Translational Medicine · 2025 · 8 citations
    10. Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects Folia Histochemica et Cytobiologica · 2026
    11. cis-Element- and Transcriptome-Based Screening of Root Hair-Specific Genes and Their Functional Characterization in Arabidopsis Plant physiology · 2009 · 188 citations
    12. Zinc in the Soil and Its Importance for the Plants and Human Health. An integrated review Middle East journal of applied sciences · 2021
    13. Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells International journal of molecular sciences · 2022 · 6 citations
    14. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    15. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    16. Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human Skin Journal of Investigative Dermatology · 2002 · 155 citations
    17. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008 · 90 citations
    18. Human and animal cells under influence of different lighting and stimulus GSC Advanced Research and Reviews · 2024
    19. Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging Aging and Disease · 2026
    20. Roles for Msx and Dlx homeoproteins in vertebrate development Gene · 2000 · 234 citations
    21. Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin FEBS Journal · 2025
    22. Corticotropin releasing hormone and the skin Frontiers in bioscience · 2006 · 137 citations
    23. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells 2007 · 66 citations
    24. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    25. Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome Biomedicines · 2022 · 45 citations
    26. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    27. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    28. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    29. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations
    30. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016 · 59 citations