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    Glossary c-Jun

    protein regulating gene expression, affecting cell processes and hair growth

    c-Jun is a protein that plays a crucial role in regulating gene expression, which means it helps control which genes are turned on or off in a cell. It is part of the AP-1 (activator protein-1) transcription factor complex and is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. In the context of hair and alopecia, c-Jun can influence hair follicle development and cycling, potentially impacting hair growth and loss.

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    1. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis Carcinogenesis · 2003 · 138 citations
    2. Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity 2007 · 31 citations
    3. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway Drug Design Development and Therapy · 2017 · 18 citations
    4. 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway Journal of Investigative Dermatology · 2023
    5. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway DOAJ (DOAJ: Directory of Open Access Journals) · 2017
    6. 446 Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway The Journal of Sexual Medicine · 2018
    7. sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation Stem cells · 2016 · 9 citations
    8. JUNB affects hair follicle development and regeneration by promoting the proliferation of dermal papilla cells in goat Chemical and Biological Technologies in Agriculture · 2023 · 1 citations
    9. Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity Cancer Research · 2006 · 70 citations
    10. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    11. An effective range of polydeoxyribonucleotides is critical for wound healing quality Molecular Medicine Reports · 2018 · 22 citations
    12. Role of bulge epidermal stem cells and TSLP signaling in psoriasis EMBO molecular medicine · 2019 · 19 citations
    13. Trichosanthes kirilowii Extract Promotes Wound Healing through the Phosphorylation of ERK1/2 in Keratinocytes Biomimetics · 2022 · 16 citations
    14. Hair Growth Stimulation Effect of Centipeda minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021 · 14 citations
    15. A Case of Virilizing Brenner Tumor in a Postmenopausal Woman With Stromal Androgenic Activity International Journal of Gynecological Pathology · 2006 · 6 citations
    16. Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells Cellular and Molecular Biology · 2025
    17. Would you recognize this lesion as a gumma syphilitica? Journal of The American Academy of Dermatology · 2017
    18. Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells Journal of The American Academy of Dermatology · 2017
    19. Wound management in hidradenitis suppurativa Journal of The American Academy of Dermatology · 2017
    20. P140 Light-emitting diode light regulates the proliferation of human outer root sheath cells via Wnt/β -catenin and ERK pathway 프로그램북(구 초록집) · 2016
    21. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    22. USING THE FROG EPIDERMIS TO UNCOVER DESMOSOME FUNCTION AND REGULATION IN THE DEVELOPING EMBRYO VCU Scholars Compass (Virginia Commonwealth University) · 2018
    23. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
    24. Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer EBioMedicine · 2019 · 13 citations
    25. Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis Journal of Investigative Dermatology · 2007 · 9 citations
    26. Phenotypic, transcriptomic, and genomic analyses reveal the spatiotemporal patterns and associated genes of coarse hair density in goats 动物学研究 · 2025 · 3 citations
    27. The Molecular Mechanism Underlying the Proliferating and Preconditioning Effect of Vitamin C on Adipose-Derived Stem Cells Stem Cells and Development · 2014 · 42 citations
    28. Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation Stem cells translational medicine · 2014 · 8 citations
    29. Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report Frontiers in genetics · 2022
    30. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity Cell reports · 2018 · 25 citations