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The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

The Rotterdam Study aims to understand various diseases in older adults.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Hair loss needs more research for better treatments.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.