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Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

Nail stem cells and Wnt signaling are important for fingertip regeneration but not sufficient for regenerating more complex limb structures.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.

Nerves are crucial for the regeneration of various body parts in many animals.

The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.

MRL/MpJ mice's skin wounds heal with scars, unlike their ear wounds which can regenerate.

Lung repair involves both dedicated and flexible stem cells, important for developing new treatments.

BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

Mice can regenerate ear tissue without the p53 protein.

Humans have limited regenerative abilities, but new evidence shows the adult brain and heart can regenerate, and future treatments may improve this by mimicking stem cell environments.

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.