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Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Hair loss affects self-esteem and quality of life; treatments can help.

Fluoxetine was not effective in treating hair-pulling disorder in the short term.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Testosterone's muscle-building effects do not require its conversion to DHT.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Skin fat helps with body temperature control and has other active roles in health.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Targeting the skin's endocannabinoid system could help treat skin disorders.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Neurosteroids show promise for treating epilepsy and more research is needed.