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This research found that the new combination drug Predstanormix Duo, with dutasteride and tamsulosin, is bioequivalent to established treatments for benign prostatic hyperplasia, showing similar pharmacokinetics and safety, potentially improving treatment availability and adherence in high-risk patients.

This chapter reviews various types of aromatic compounds and provides references, but reports no new experimental results.

In this study, researchers optimized the soft drug AR antagonist 14-P1 to create candidate 39, which demonstrated effective AR antagonism and safety in a hair-growth mouse model, showing similar efficacy to pyrilutamide but with quicker onset and a lower risk of systemic toxicity.

This study found that artocarpin delivered via alginate/chitosan microparticles effectively suppressed the growth of hamster flank organs compared to artocarpin in solution form, without significant systemic effects.

This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.

Increasing TSPO in the brain may help improve memory problems.

This study developed a faster method to analyze fatty acid ethyl esters in human hair, potentially distinguishing alcohol consumption levels more efficiently.

This study found that topical phenylephrine, an α1-AR agonist, significantly reduced hair shedding and increased epilation force threshold in women experiencing traction alopecia during cosmetic procedures.

This article reviews the legal processes for international athletes facing disciplinary actions and suggests enhanced legal representation and procedural changes to improve their access to justice, but reports no new results.

This review identified two promising therapeutic targets for drug repurposing to treat refractory angina in patients with angina pectoris without obstructive coronary artery disease: endothelin-1 receptor blockers and soluble guanylate cyclase stimulators.

This review discusses the structural properties, pharmacological effects, and clinical applications of neurotoxins on synapses, reporting no new experimental results.

This study found that AR-positive breast cancer cell lines are more sensitive to the dual PI3K/mTOR inhibitor NVP-BEZ235 compared to AR-negative cells.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

This study reported that a novel vasodilator drug called TOP-M119, when delivered using a specially designed dissolving microneedle system, showed enhanced targeting of hair follicles and effectiveness in treating alopecia, demonstrated through in vitro, ex vivo, and in vivo studies involving mouse skin.

This review discusses the off-label use of drugs like Minoxidil, Aripripazole, and others, providing insights for physicians and pharmacists but reports no new clinical findings.

This case study reported that an 18-year-old woman ingested a large amount of topical minoxidil, leading to symptoms like low blood pressure, increased heart rate, and elevated liver enzymes, but recovered fully after treatment. Minoxidil toxicity may rarely cause abnormal liver enzyme levels.

In this article, the authors describe how drug repurposing, supported by large-scale data and artificial intelligence, can make drug discovery more cost-effective and expedient compared to traditional methods, despite certain regulatory challenges.

In this study, the researchers reviewed psychiatric drugs approved between 2002 and 2022 to analyze trends in drug repurposing, finding an increased application of repurposing methods, especially through fixed-dose combinations, and highlighting technologies like SmartCube® to predict efficacy from animal models.

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

The woman likely died from acute arsenic poisoning, not chronic exposure.

Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.

This study found that the evodiamine derivative 2-16 exhibited the highest antitumor activity and a broad spectrum of activity against various human cancer cell lines, with improved solubility.

This study found that the optimized AR antagonist candidate 39, in a hair-growth mouse model, achieved similar efficacy to pyrilutamide with faster onset and favorable safety, suggesting a promising approach for developing topical treatments with low systemic toxicity for androgenetic alopecia.

This review discusses current treatments for benign prostatic hyperplasia and reports on the cost-effectiveness of alpha1-selective adrenergic receptor antagonists compared to other pharmacologic and invasive therapies without presenting new clinical results.

In this study, the researchers reported that the optimized compound 39 demonstrated potent AR antagonism and favorable pharmacokinetics in a hair-growth mouse model, achieving similar efficacy to pyrilutamide with faster onset and preserved safety, offering promise for next-generation topical AR antagonist development.

This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.

In this study, researchers identified several active metabolites in Eclipta alba, demonstrated strong interaction with Alzheimer's disease proteins, and found that 28 days of treatment improved memory without significant toxicity in rats, suggesting potential pathways for treating Alzheimer's.

In this study, pre-treatment with steam towel, l-menthol, and CA-carpronium enhanced the absorption of minoxidil nanoparticles in mice, potentially increasing therapeutic efficiency without side effects.