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research Editorial Comment
research Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials
5α-Reductase inhibitors can negatively impact sexual function.
research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome
research New Methods of Endocrine Management of Prostatic Cancer
New hormonal therapies can help treat advanced prostate cancer but may cause testicular issues.
research 5 Alpha-Reductase Inhibitors: What's New?
A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.
research Methylation of SRD5A2 in the Blood as a Novel Biomarker to Predict Sensitivity to 5-ARI Treatment
SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.
research Effects of Castration on Benign Prostatic Hyperplasia
Castration significantly reduces prostate size and BPH symptoms.
research Effect of the Dual 5α-Reductase Inhibitor Dutasteride on Markers of Tumor Regression in Prostate Cancer
Dutasteride may help treat prostate cancer by causing cancer cells to shrink and die.
research The Cardiovascular Safety of Dutasteride
Dutasteride is as safe for the heart as finasteride.
research Patterns of Care for Newly Diagnosed Benign Prostatic Hyperplasia in the United States
Most care for benign prostatic hyperplasia follows guidelines, but 5-α reductase inhibitors are often used incorrectly.
research Post-Finasteride Syndrome
research Clinical Effectiveness of Bilateral Orchiectomy in Reducing Anti-Androgens in Transgender Females
Bilateral Orchiectomy effectively reduces the need for anti-androgen medication in most transgender females.
research Dihydrotestosterone And The Prostate: The Scientific Rationale For 5α-Reductase Inhibitors In The Treatment Of Benign Prostatic Hyperplasia
Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.
research Efficacy and Safety of SER120 Nasal Spray in Patients with Nocturia: Pooled Analysis of Two Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trials
SER120 nasal spray effectively reduces nighttime urination and is safe for patients.
research Comparison of Clinical Trials with Finasteride and Dutasteride
research Cardiovascular Effects of Hormone Therapy for Prostate Cancer
Hormone therapy for prostate cancer can increase heart risks, especially in men with heart conditions.
research Role of 5 Alpha-Reductase Inhibitors in the Management of Prostate Cancer
5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.
research Folliculin Deficient Renal Cancer Cells Show Higher Radiosensitivity Through Autophagic Cell Death
Kidney cancer cells without folliculin are more sensitive to radiation due to increased self-eating cell death.
research Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial
Dutasteride can reduce night-time urination but it doesn't improve sleep quality.
research Postoperative Urinary Retention Is an Independent Predictor of Short-Term and Long-Term Future Bladder Outlet Procedure in Men
Older men with postoperative urinary retention are more likely to need future bladder procedures.
research Seminal Vesiculoscopy for Diagnosis and Management of Hematospermia
The procedure involving seminal vesiculoscopy, TURED, and balloon dilation effectively treated a man's hematospermia and improved his dysorgasmia.
research Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone
Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
research Does Treatment with Dutasteride or Finasteride Have Impact on Renal Morphology? Experimental Study
The study investigated the impact of dutasteride and finasteride on renal morphology in male rats over 40 days. Both drugs caused significant increases in serum urea and creatinine levels, indicating renal damage. Kidney weights, volumes, and the number of glomeruli per kidney were notably reduced, with dutasteride causing more severe effects than finasteride. Dutasteride led to a 51.6% reduction in glomeruli, while finasteride caused a 26.8% reduction. The study concluded that both drugs caused morphological and functional kidney damage, with dutasteride having a more pronounced impact. These findings suggested the need for careful consideration of renal function when prescribing these medications, especially for patients with a history of renal disease.
research How Do 5-Alpha-Reductase Inhibitors Change PSA Density in Patients on Active Surveillance?
5-alpha-reductase inhibitors lower PSA density but higher PSA density indicates disease progression.
research Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database
Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.
research Drugs Associated the Most with Male-Factor Infertility: Assessment of the 2010-2020 Food and Drug Administration Pharmacovigilance Database
Finasteride and testosterone are the drugs most linked to male infertility, but many other potential drugs may be under-reported.
research Statewide Geographic Price Variation of Generic BPH Medications
Big chain pharmacies in Pennsylvania charge significantly more for generic BPH medications than independent pharmacies, but independent pharmacies have more regional price variation.
research Trends in 5-Alpha Reductase Inhibitor Use Before and After the Food and Drug Administration Safety Warning
Prescriptions for 5-alpha reductase inhibitors dropped significantly after the FDA's safety warning, especially for men with benign prostatic hyperplasia.