Hypertensive Crisis Associated with St. John’s Wort

April 2002 in “ The American Journal of Medicine ”

Sona Patel, Robert Robinson, Martha S. Burk

St. John's Wort hypertensive crisis monoamine oxidase inhibitor tyramine

TLDR St. John's Wort can cause dangerous high blood pressure if taken with certain foods.

A 41-year-old man experienced a hypertensive crisis and delirium after consuming St. John's Wort along with tyramine-rich foods. His blood pressure was 210/140 mm Hg, and he was disoriented. Laboratory tests ruled out other causes, suggesting that St. John's Wort may act as a monoamine oxidase inhibitor, leading to severe hypertension when combined with tyramine-rich foods. This case highlighted the need for caution when using St. John's Wort, especially with certain dietary habits.

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