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    Did you mean AKT signaling pathway?
    Glossary AKT signaling pathway

    regulates cell growth, survival, and metabolism

    The AKT signaling pathway, also known as the Protein Kinase B (PKB) pathway, is a crucial cell signaling system that regulates various cellular processes, including growth, survival, and metabolism. It is activated by growth factors and other extracellular signals, leading to the phosphorylation and activation of AKT, which then influences numerous downstream targets to promote cell proliferation and inhibit apoptosis (cell death). This pathway is significant in many physiological contexts and is often implicated in cancer and other diseases due to its role in cell survival and growth.

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    1. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    2. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/ ¥-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019 · 37 citations
    3. Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing Journal of Biomedical Science · 2023 · 19 citations
    4. Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways Archives of Dermatological Research · 2019 · 18 citations
    5. Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway BMC Complementary and Alternative Medicine · 2019 · 10 citations
    6. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2021 · 4 citations
    7. TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs Stem Cell Research & Therapy · 2025
    8. Effect of Scenedesmus deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells Applied Sciences · 2025
    9. Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model Journal of Biomedical Nanotechnology · 2022
    10. Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway International Journal of Molecular Sciences · 2020 · 7 citations
    11. Comment on “CCN1 secreted by human adipose‐derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway” International Wound Journal · 2023 · 1 citations
    12. Peer Review #1 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.1)" 2022
    13. Peer Review #2 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.1)" 2022
    14. Peer Review #2 of "Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway (v0.2)" 2022
    15. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026
    16. Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits Animal nutrition · 2021 · 10 citations
    17. Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads Journal of Bioscience and Bioengineering · 2022 · 12 citations
    18. Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway PeerJ · 2022 · 4 citations
    19. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021 · 30 citations
    20. Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway Stem Cell Research & Therapy · 2025
    21. Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway Frontiers in Pharmacology · 2024 · 3 citations
    22. Dental pulp stem cell exosomes promote angiogenesis via the PI3K/Akt signaling pathway to treat androgenetic alopecia Stem Cell Research & Therapy · 2026
    23. Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway Journal of Ovarian Research · 2025
    24. PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration Stem Cell Research & Therapy · 2020 · 30 citations
    25. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations
    26. Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway Frontiers in Pharmacology · 2023
    27. Corrigendum: Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway Frontiers in Pharmacology · 2023
    28. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway Life Sciences · 2019 · 28 citations
    29. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    30. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024