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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Tofacitinib may help treat severe hair loss, but more research is needed.

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

TSH is usually the only test needed to check thyroid function in primary care.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Acne treatment varies, with topical and systemic therapies effective, and more research needed on treatment order and long-term effects.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Advanced human skin models improve drug development and could replace animal testing.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Chronic Telogen Effluvium may resolve after years and is diagnosed by examining the patient's history and clinical signs, with treatment aimed at underlying causes and possibly minoxidil.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

PCOS symptoms change with age; younger women have higher androgen levels and less metabolic issues, while older women face more metabolic challenges despite milder PCOS symptoms.

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

Spironolactone is an effective and well-tolerated first-line treatment for hidradenitis suppurativa in women.

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

The cosmetic industry should adapt to the varied beauty standards of ethnic groups and offer specialized treatments.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

LGBT individuals have unique skin health needs, including higher STD risks and side effects from gender-affirming treatments, requiring dermatologists to offer knowledgeable and culturally competent care.

PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

Hormonal therapies are safe and effective for treating adult women's acne.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.