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The conclusion is that the risk of losing significance in meta-analysis results increases with smaller effects and more missing data, and using the median standard deviation for imputation is recommended.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Testosterone's muscle-building effects do not require its conversion to DHT.

Aromatherapy with certain essential oils is a safe and effective treatment for hair growth in alopecia areata patients.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Finasteride may cause long-lasting sexual side effects.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Foals with Rhodococcus equi infection often have other health problems that lower their chances of survival.

PRP injections improve hair thickness for baldness.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Ginseng is possibly safe but its effectiveness is unclear due to poor quality studies and mixed results.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Alpha-hydroxy acids, like glycolic acid, safely improve skin issues and work on all skin types.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

The document concludes that follicular unit transplantation offers more natural results and better graft survival than older hair transplant methods.

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

Teriflunomide is safe and tolerable for treating relapsing-remitting multiple sclerosis, with manageable side effects.

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Low-level laser therapy is safe and can increase hair growth for male and female pattern hair loss.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.