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    Glossary GABAA Receptors

    ion channels in the brain that reduce neuronal excitability

    GABAA receptors, also known as Gamma-Aminobutyric Acid Type A receptors, are a class of receptors in the brain that respond to the neurotransmitter GABA, the primary inhibitory neurotransmitter in the central nervous system. These receptors are ion channels that, when activated, allow chloride ions to enter the neuron, making it less likely to fire and thus reducing neuronal excitability. This mechanism is crucial for regulating brain activity and is a target for various medications, including sedatives, anxiolytics, and anticonvulsants.

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    1. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997 · 416 citations
    2. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    3. Polymorphism of the Androgen Receptor Gene is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001 · 299 citations
    4. Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6 Journal of Biological Chemistry · 2009 · 253 citations
    5. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    6. Eph Receptors and Ephrins: Therapeutic Opportunities Annual Review of Pharmacology and Toxicology · 2014 · 222 citations
    7. The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors Drug Metabolism Reviews · 2006 · 219 citations
    8. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 207 citations
    9. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    10. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004 · 180 citations
    11. The <i>hairless</i> gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes & Development · 2001 · 178 citations
    12. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Proceedings of the National Academy of Sciences · 1984 · 164 citations
    13. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    14. Localization of sex steroid receptors in human skin. PubMed · 2004 · 147 citations
    15. Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development Frontiers in Cellular Neuroscience · 2019 · 142 citations
    16. The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003 · 130 citations
    17. Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp 1992 · 124 citations
    18. Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth Developmental Biology · 1983 · 124 citations
    19. The role of androgen and androgen receptor in skin-related disorders Archives of Dermatological Research · 2012 · 124 citations
    20. Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations Calcified Tissue International · 1997 · 123 citations
    21. A role of melatonin in neuroectodermal‐mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors ˜The œFASEB journal · 2005 · 122 citations
    22. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. PubMed · 1998 · 122 citations
    23. Frizzled Receptors in Development and Disease 2016 · 114 citations
    24. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 108 citations
    25. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    26. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    27. Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1 The Journal of Clinical Endocrinology and Metabolism · 2001 · 93 citations
    28. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling Endocrinology · 2005 · 92 citations
    29. NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor The EMBO Journal · 2019 · 91 citations
    30. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations