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    Glossary Rapamycin

    drug that inhibits mTOR to suppress immune response

    Rapamycin, also known as Sirolimus, is a drug originally discovered in soil bacteria from Easter Island. It is primarily used as an immunosuppressant to prevent organ transplant rejection and has shown potential in extending lifespan and treating certain diseases by inhibiting a protein called mTOR, which regulates cell growth and metabolism.

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    Research 30 of 787

    1. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    2. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    3. Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth Journal of Dermatological Science · 1995 · 20 citations
    4. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    5. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study ˜The œAmerican journal of gastroenterology · 2021 · 13 citations
    6. Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy? PLoS ONE · 2014 · 12 citations
    7. Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles Pharmaceutics · 2022 · 7 citations
    8. Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus Australasian journal of dermatology · 2016 · 6 citations
    9. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    10. Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates 2016 · 4 citations
    11. LAM/TSC Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis. Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin Journal of Cytology & Histology · 2014 · 2 citations
    12. Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells Journal of Investigative Dermatology · 2021 · 1 citations
    13. Angelica sinensis promotes cortical regeneration of the thymus in mice with acute thymic involution induced by short-term rapamycin treatment Journal of Zhejiang University (Medical Sciences) · 2026
    14. Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes Theranostics · 2025
    15. Low-dose rapamycin microdepots promote hair regrowth via autophagy modulation Journal of Pharmaceutical Investigation · 2025
    16. A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids. PubMed · 2024
    17. Valproic acid and/or rapamycin preconditioning protects hair follicle stem cells from oxygen glucose serum deprivation-induced oxidative injury via activating Nrf2 pathway. PubMed · 2024
    18. Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease Innovation in aging · 2020
    19. Prevention of Murine Sclerodermatous Chronic Graft-Versus-Host Disease by Rapamycin Biology of blood and marrow transplantation · 2013
    20. Effect of immunosuppressive ppiase inhibitors, cyclosporin A, FK506, ascomycin and rapamycin on hair growth initiation Journal of dermatological science · 1994
    21. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet British Journal of Dermatology · 2016 · 93 citations
    22. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin Experimental Dermatology · 2015 · 74 citations
    23. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    24. Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin? Experimental Dermatology · 2009 · 18 citations
    25. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    26. Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation Journal of cutaneous pathology · 2019 · 4 citations
    27. Elevated Mammalian Target of Rapamycin (mTOR) Gene Expression in Acne Vulgaris patients 2023
    28. The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis International Journal of Molecular Sciences · 2018 · 177 citations
    29. Combination Of Regulatory T Cells and Rapamycin As Treatment For Experimental Chronic Graft-Versus-Host Disease Blood · 2013
    30. Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition Cell Cycle · 2006 · 295 citations