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Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

5-alpha reductase inhibitors may reduce bladder cancer recurrence and improve survival.

Estrogen deficiency can reduce the enzyme activity needed to activate vitamin D.

Finasteride doesn't affect hormone levels in normal men.

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

LAAM caused developmental toxicity in tolerant rats without causing birth defects.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

Using 5-alpha-reductase inhibitors may improve bladder cancer survival in men.

Oral finasteride and dutasteride may negatively affect erectile function in rats.

Taking 5-alpha reductase inhibitors does not increase breast cancer risk in men.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Four-amino acid part makes enzyme sensitive to finasteride.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Most patients treated with low-dose alpha-interferon for malignant melanoma experienced skin side effects, with hair loss being the most frequent.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

A woman's hair loss during treatment with specific hepatitis C drugs grew back after stopping the medication.

Finasteride and minoxidil together promote hair growth better than either alone.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.