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research Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

6 citations , June 2011 in “British Journal of Dermatology”

This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.

research Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia

22 citations , October 2012 in “Journal of Investigative Dermatology”

This study found that C57BL/6 mice with a diet containing specific levels of vitamin A showed alterations in retinoid metabolism and increased frequency of cicatricial alopecias, suggesting dietary factors may play a role in this condition.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.

research Geriatric Dermatologic Therapy

February 2026

This source provides medical information intended solely for licensed professionals and emphasizes that it is not a substitute for medical advice, diagnosis, or treatment decisions, which remain the responsibility of treating physicians.

research Cellular retinol‐binding protein‐1 expression increases with increasing clinical severity of alopecia areata

2 citations , December 2018 in “Journal of cosmetic dermatology”

This study observed a significant increase in cellular retinol-binding protein-1 expression in lesional skin of patients with alopecia areata compared to healthy controls, suggesting its potential role in the disease's pathogenesis.

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community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 2 years ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

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