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Mutations in the PTPRQ gene cause significant balance issues in mice due to hair bundle defects in the inner ear.

Ptprq has multiple forms that change during inner ear development.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

miR-199a-3p controls hair growth and is linked to alopecia areata.

Hairless mammals evolved quickly in both gene and non-gene areas related to skin and hair.