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Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

research Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

12 citations, March 1995 in “Journal of the American Chemical Society”

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

research Determination of Protonation State in Molecular Salt of Minoxidil and 2,4-Dihydroxybenzoic Acid Through a Combined Experimental and Theoretical Study: Influence of Proton Transfer on Biological Activities

12 citations, September 2021 in “Journal of molecular structure”

The MXD/24HA salt is more effective for hair growth than raw MXD.

research Voltammetric Reduction of Finasteride at Mercury Electrode and Its Determination in Tablets

21 citations, May 2008 in “Talanta”

New, cheaper method measures finasteride in tablets accurately and quickly.

research Advances in Chitosan-Based Nanoparticles for Drug Delivery

96 citations, September 2021 in “International Journal of Molecular Sciences”

Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.

research Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology

100 citations, November 2017 in “EMBO Reports”

Metabolic signals and cell shape influence how cells develop and change.

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Community Join

4 / 4 results

community 1.5 years on fin and min (24 yo). Start early guys, it’s worth it.

in Progress Pictures 1167 upvotes 1 year ago

The conclusion of the conversation is that the user "CheckHopeful" has seen significant improvement in their hair loss after using finasteride and minoxidil for 1.5 years. Some users discuss side effects and suggest adjusting the dosage or trying topical finasteride or RU58841.

community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

in Question 4 upvotes 8 years ago

The conversation discusses the potential of Sanguisorba Officinalis Root Extract as a treatment for hair loss by inhibiting FGF-5. The user also mentions the product évolis, which is based on this extract but is only available in the US and Australia.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 1 year ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.