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Glossary Protein Stability

ability of a protein to maintain its functional shape

Protein stability refers to the ability of a protein to maintain its three-dimensional structure under various conditions, such as changes in temperature, pH, or the presence of chemicals. For a layperson, think of it like a puzzle that needs to stay together to work properly; if the pieces fall apart, the puzzle is useless. For professionals, protein stability is crucial because it affects the protein's functionality and its potential use in medical or industrial applications.

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research Identification of compound heterozygous mutations in AP1B1 leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome

11 citations , January 2021 in “British Journal of Dermatology”

This report describes a new case of syndromic ichthyosis caused by compound heterozygous mutations in AP1B1, detailing the associated clinical features and molecular consequences in the patient.

research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia

2 citations , May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study describes a family where a TP63 mutation was linked with prominent alopecia and mild ectodermal dysplasia features.

research Booby Trap: Cancer gene spurs production of DNA-assaulting chemicals that alert and defuse rescue molecule (Cancer; Oxidative damage)

June 2002 in “Science of aging knowledge environment”

This study suggests that the oncogene c-Myc can induce DNA damage by increasing reactive oxygen species, potentially overriding p53 and contributing to genetic instability in cancer cells.

research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24

25 citations , August 2007 in “Molecular Therapy”

This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.

research Deciphering principles of morphogenesis from temporal and spatial patterns on the integument

19 citations , April 2015 in “Developmental Dynamics”

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

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community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Why don't we all just take 2.5mg dutasteride?

in Finasteride/Dutasteride 45 upvotes 11 months ago

Switching from finasteride and minoxidil to a higher dose of dutasteride for hair loss is debated due to potential side effects. Many suggest starting with lower doses or sticking to finasteride if effective.

community Hairloss has destroyed my Life completely

in Chat 339 upvotes 1 year ago

A young person is distressed about rapid hair loss despite using finasteride and recently starting oral minoxidil. Many suggest continuing treatment, considering dutasteride, and seeking therapy for mental health support.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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