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Did you mean Progesterone Receptor?

Glossary Progesterone Receptor

protein in cells that binds to the hormone progesterone

The Progesterone Receptor (PR) is a protein found inside cells that binds to the hormone progesterone. This receptor is crucial for regulating various reproductive processes, including the menstrual cycle and pregnancy. In the context of hair and alopecia, PRs can influence hair growth cycles and are a target for treatments aimed at conditions like androgenetic alopecia.

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research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

This study found no significant association between selected gene variants and female pattern hair loss, suggesting these genes might not be involved in its development.

research Pharmacology of different progestogens: the special case of drospirenone

104 citations , January 2005 in “Climacteric”

This review discusses the pharmacological properties of progestins used in contraception and hormone replacement therapy, focusing on drospirenone's unique effects, but reports no new experimental findings.

research The effects of sex-steroids and menstrual cycle/oestrous phases on knee ligament laxity in humans and rodents / Firouzeh Dehghan

January 2014

This study found that in both rodents and humans, knee laxity increased at certain phases of the reproductive cycle due to sex-steroid influence, particularly under high levels of estrogen and progesterone.

research Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice

180 citations , June 2004 in “Journal of Pharmacology and Experimental Therapeutics”

This study found that progesterone's antiseizure effects in mice occurred primarily through conversion to allopregnanolone, rather than through the progesterone receptor, as evidenced by results in PR knockout mice.

research Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice

35 citations , January 2005 in “Brain Research”

This study indicates that progesterone’s anesthetic activity in PR knockout mice is not due to progesterone receptors but is partially mediated by the neurosteroid allopregnanolone through GABAA receptor potentiation.

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community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 2 years ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Popular hair loss drug linked to higher suicide risk: compared to non-users, finasteride (Proscar/ Propecia) users have a markedly increased risk of depression, anxiety, and suicidal thoughts. Over 30 years of observation, 19,320 suicides were expected.

494 upvotes 11 months ago

Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hair loss itself. The link between finasteride and mental health effects is debated, with varying user experiences.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

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