11 citations
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March 2015 in “Life sciences” This study found that using conditioned medium from vitamin D3 pre-activated preadipocytes enhanced hair regeneration in mice by promoting angiogenesis.
130 citations
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March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that in mice, epidermal Wnt/β-catenin signaling influences adipocyte differentiation and hair growth, suggesting its critical role in synchronizing adipogenesis with the hair growth cycle.
37 citations
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October 2021 in “Journal of Clinical Investigation” This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.
18 citations
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January 2000 in “Food Science and Technology Research” In this study, partially purified apple polyphenols were found to inhibit preadipocyte differentiation in mouse cells by reducing GPDH activity and triglyceride accumulation.
In this study, researchers used a mouse model to identify an adipocyte-to-fibroblast conversion pathway that promotes mast-cell recruitment and dermal fibrosis in atopic dermatitis, suggesting a potential therapeutic approach to block this process and reduce inflammation and fibrosis.