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In this study, PDO, PLLA, and PCL thread implants in ageing rat skin did not alter MMP1 gene expression but maintained collagen levels similar to young skin without UV-B exposure, suggesting possible benefits for skin collagen but not gene expression modification.

This network meta-analysis found that for female pattern hair loss, microneedling combined with minoxidil ranked highest for hair density and patient satisfaction, while poly-L-lactic acid threads plus minoxidil led in hair diameter; however, the evidence is uncertain and lacks placebo-controlled trials.

This study found that combining poly-l-lactic acid microthread therapy with minoxidil improved hair density and appearance more effectively than minoxidil alone in women with androgenetic alopecia.

This research found that hyaluronic acid increased cell proliferation and type I collagen more effectively than poly-L-lactic acid in both human fibroblast cultures and rat dermis.

This study reported that combining Poly-D,L-Lactic Acid with Platelet-Rich Plasma for facial rejuvenation reduced wrinkle severity and improved skin tone and hyperpigmentation in a 45-year-old female patient.