Search

for
Search:

GlossaryPlakophilin-1

protein crucial for cell adhesion in skin and hair

Plakophilin-1 (PKP1) is a protein that plays a crucial role in the formation and maintenance of desmosomes, which are structures that help cells stick together, particularly in tissues that experience a lot of stress, like the skin and heart. Mutations in the gene encoding Plakophilin-1 can lead to skin disorders and hair loss conditions, such as ectodermal dysplasia/skin fragility syndrome, highlighting its importance in maintaining the integrity of epithelial tissues.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 68 results

research The Genetics of Hair Shaft Disorders

59 citations, June 2008 in “Journal of The American Academy of Dermatology”

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

research Folliculin Interacts With P0071 (Plakophilin-4) and Deficiency Is Associated With Disordered RhoA Signalling, Epithelial Polarization, and Cytokinesis

47 citations, September 2012 in “Human molecular genetics online/Human molecular genetics”

Folliculin deficiency causes problems with cell division and positioning due to disrupted RhoA signaling and interaction with p0071.

research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

March 2022

Hairless mammals evolved quickly in both gene and non-gene areas related to skin and hair.

research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations, August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Alopecia in Epidermolysis Bullosa

21 citations, November 2009 in “Dermatologic Clinics”

The document suggests that certain protein deficiencies and scalp blistering in Epidermolysis Bullosa may cause hair loss.

View more "plakophilin1" in research →

Community Join

0 / 0 results

— no results