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research Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

23 citations , May 2005 in “British Journal of Cancer”

This study reported the feasibility of detecting six cell-cycle-related nuclear markers in plucked human scalp and eyebrow hair, providing valuable insights for future intervention studies.

research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products

188 citations , October 2012 in “The AAPS Journal”

This review discusses strategies for developing semi-solid topical generic products to match the quality of reference-listed drugs, using concepts like quality by design and reverse-engineering, but reports no new results.

research Plucked Human Hair Shafts and Biomolecular Medical Research

8 citations , January 2013 in “The scientific world journal/TheScientificWorldjournal”

This review explores the potential use of plucked hair follicles in regenerative medicine and diagnostics but presents no new research findings.

research Niosomes as Vesicular Nanocarriers in Cosmetics: Characterisation, Development and Efficacy

14 citations , February 2025 in “Pharmaceutics”

This review highlights recent advancements in using niosomes as nanocarriers for improved delivery and sustained release of active cosmetic compounds, discussing their properties, applications, and future potential in cosmetic chemistry.

research Topical Melatonin for Treatment of Androgenetic Alopecia

39 citations , January 2012 in “International Journal of Trichology”

This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community The fact 2.5mg Dutasteride pills don't exist is f*cking ridiculous (RANT)

in Finasteride/Dutasteride 4 upvotes 10 months ago

The conversation discusses the frustration over the unavailability of 2.5mg dutasteride soft gels, with some users suggesting higher doses for better scalp DHT suppression. Concerns about side effects and the necessity of DHT are debated, with some users advocating for alternative treatments like RU58841 and oral minoxidil.

community DHT reduction in the scalp for all doses of dutasteride is now available.

in Finasteride/Dutasteride 357 upvotes 1 year ago

Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.

community Sexual Dysfunction in Those with Androgenetic Alopecia on Dutasteride Versus Finasteride

in Finasteride/Dutasteride 113 upvotes 1 year ago

Dutasteride and finasteride have similar risks of sexual dysfunction for treating androgenetic alopecia. Users experience varying side effects, indicating individual differences in drug reactions.

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Hair Loss TreatmentsTrichology
Institute of Trichology StudiesFort Worth, TX · US

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