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GlossaryPPAR Agonists (Peroxisome Proliferator-Activated Receptor Agonists)

activate nuclear receptors to regulate metabolism and inflammation

PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations, January 2017 in “PPAR Research”

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

research Hormone Therapy in Acne

24 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

research Cardiovascular Profile of Pharmacological Agents Used for the Management of Polycystic Ovary Syndrome

4 citations, January 2019 in “Therapeutic Advances in Endocrinology and Metabolism”

Medications for PCOS don't seem to raise heart disease risk.

research Recent Progress in Prostaglandin F2α Ethanolamide (Prostamide F2α) Research and Therapeutics

43 citations, July 2013 in “Pharmacological reviews”

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

research Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

2 citations, December 2022 in “Journal of Clinical Medicine”

Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.