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Glossary Perifollicular

area surrounding hair follicle

Perifollicular refers to the area surrounding a hair follicle. In medical and dermatological contexts, this term is often used to describe conditions or observations, such as inflammation or fibrosis, that occur around the hair follicles. For example, perifollicular inflammation is a common feature in certain types of hair loss, like alopecia areata, where the immune system attacks the hair follicles.

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Research

5 / 1000+ results

research Frontal Fibrosing Alopecia Involving the Limbs Shows Inflammatory Pattern on Histology: A Review of 13 Cases

7 citations , August 2019 in “American Journal of Dermatopathology”

This study found that limb hair loss in frontal fibrosing alopecia is inflammatory and permanent, but lacks the classic scarring features seen in scalp alopecia, prompting potential misdiagnosis as alopecia areata.

research Pediatric Lichen Planopilaris: Clinicopathologic Study of Four New Cases and a Review of the Literature

16 citations , June 2015 in “Pediatric dermatology”

This review discusses lichen planopilaris in children and highlights its rarity, potential for misdiagnosis, and need for suspicion in atypical or treatment-resistant alopecia cases, but reports no new results.

research Clinicopathologic lessons in distinguishing cicatricial alopecia: 7 Cases of lichen planopilaris misdiagnosed as discoid lupus

15 citations , September 2014 in “Journal of The American Academy of Dermatology”

This study found that seven cases of cicatricial alopecia initially diagnosed as discoid lupus erythematosus were more consistent with lichen planopilaris based on histopathology.

research Dermoscopy of discoid lupus erythematosus: Report of two cases

13 citations , July 2014 in “The Journal of Dermatology”

Dermoscopy helped diagnose discoid lupus erythematosus in two patients without needing skin biopsies.

research Atypical Presentation of Lichen Planopilaris: Presentation of Two Cases and Review

March 2020 in “Clinical research in dermatology”

This report describes two unusual cases of lichen planopilaris in Caucasian patients, detailing features suggestive of folliculotropic mycosis fungoides and an overlap with systemic lupus erythematosus.

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Community Join

5 / 37 results

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

5 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Still have itchy scalp after 6 months on fin + keto

29 upvotes 4 months ago

The user experiences an itchy scalp despite using finasteride and ketoconazole shampoo for hair loss. Suggestions include trying different shampoos, switching to dutasteride, and using topical treatments for inflammation.

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