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Expression of Programmed Cell Death 1 Inversely Correlated With the Density of CD8+ T Cells Infiltrating Hair Follicles in Alopecia Areata

research 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

This study found that in biopsied skin samples of alopecia areata, a lower anagen/telogen ratio was associated with increased T cell infiltration, and enhancing the PD-1/PD-L1 axis may inhibit CD8+T cell infiltration and improve the condition.

research Alopecia and hair repigmentation associated with anti-programmed death-ligand 1 (PD-L1) immunotherapy

2 citations , November 2024 in “JAAD Case Reports”

Anti-PD-L1 immunotherapy can cause hair loss and unexpected hair color change, but treatment can restore hair growth and color.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.

research Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies

June 2023 in “Cancers”

This article reviews the cutaneous side effects of immune checkpoint inhibitors and targeted therapies for skin cancers, noting that while generally mild, these effects can influence treatment decisions and quality of life, underscoring the need for physicians to be aware of these adverse reactions.

research Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions

15 citations , June 2015 in “F1000Research”

This study examined immune responses to Diphencyprone and found that its induced skin reactions have higher levels of negative immune regulators compared to psoriasis, suggesting differences in immune regulation may contribute to psoriasis chronicity.

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community Only 1.5 months into treatment - is this normal or too fast?

in Progress Pictures 16 upvotes 8 months ago

A 21-year-old started treatment for androgenetic alopecia and seborrheic dermatitis with oral finasteride, topical minoxidil, anti-dandruff shampoo, and a corticosteroid solution. After 1.5 months, they noticed increased hair density and are considering switching to oral minoxidil due to scalp issues.

community Before/after 3 months, I'm seeing little hairs in areas when I thought it wasn't possible

194 upvotes 1 year ago

The user is experiencing hair regrowth after three months using minoxidil, 1.25mg finasteride, ketoconazole cream, and a 1.5mm derma roller. They are considering reducing their finasteride dose due to decreased libido.

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research 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

research Alopecia and hair repigmentation associated with anti-programmed death-ligand 1 (PD-L1) immunotherapy

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

research Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies

research Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions

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community Only 1.5 months into treatment - is this normal or too fast?

community Before/after 3 months, I'm seeing little hairs in areas when I thought it wasn't possible

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