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research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

18 citations , September 2021 in “Journal of Neuroendocrinology”

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

research Effects of Copper (II) Albumin Complex on Thermal Skin Burn

December 2012 in “Bulletin of Egyptian Society for Physiological Sciences”

This study found that topical application of copper (II) albumin complex improved healing signs in rats with full thickness thermal burns, enhancing antioxidant, anti-inflammatory, and pain modulating effects.

research C‐tactile afferents: The mystery of human emotional touch has been hidden hair‐deep

July 2025 in “The Journal of Physiology”

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

research Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone

December 2023 in “Frontiers in pharmacology”

In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.

research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

61 citations , September 2011 in “Pain”

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

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Community Join

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community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Attempting to assist people with gyno sides on finasteride

23 upvotes 2 years ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community Dutasteride might be saving me

444 upvotes 1 year ago

A user switched from finasteride to dutasteride due to side effects and saw significant hair improvement after 7 months, with no side effects from dutasteride. They also switched from topical to oral minoxidil, which may have contributed to the positive results.

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Learn

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learn Hair Transplant

How much pain will I be in after a hair transplant surgery? Pain after a hair transplant is usually mild to moderate and manageable with medication.
Will I feel pain during a hair transplant? Most patients feel minimal discomfort during a hair transplant due to local anesthesia.
How long does pain last after a hair transplant? Mild discomfort after a hair transplant typically lasts a few days to a week.
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learn Scalp Micropigmentation

Will I experience pain after the scalp micropigmentation treatment? You may feel discomfort during the procedure and soreness afterward.

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Clinics

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Experts

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Hair System Specialist
Suparno Paine
Kolkata, West Bengal, India

Suparno Paine