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GlossaryPain Mediator (pain modulator)

substance that transmits and modulates pain signals in the body

A pain mediator, also known as a pain signaling molecule, is a substance in the body that plays a crucial role in the transmission and modulation of pain signals. These molecules, such as prostaglandins, bradykinin, and substance P, are released in response to injury or inflammation and interact with nerve receptors to amplify the sensation of pain. Understanding pain mediators is essential for developing effective pain management therapies.

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community Father trying to save his 17 year old son from MPB

External_Occasion_52 in Progress Pictures 160 upvotes 3 years ago

Father assists son with hair loss using Finasteride Propecia. Son's hair improves, considers adding Minoxidil or Dutasteride for better results.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 823 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

Busy-Order-9093 in Chat 237 upvotes 3 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Oral min 2.5mg closing in on 3 months

_the_orange_box_ in Progress Pictures 372 upvotes 1 year ago

_the_orange_box_'s experience using oral minoxidil, with discussion about finasteride and the potential side effects of both treatments. Other users shared their own experiences related to hair loss treatments.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

HMI115_GIGACHAD in Research/Science 126 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

Combfromhell in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community New Treatments, and a Huge Group Buy with Lots of Research

jumpmanmm in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

obafootballinstinct in Research/Science 136 upvotes 6 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

Substantial_Way_2921 in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

MagicBold in Research 413 upvotes 2 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

MagicBold in Research/Science 2 upvotes 2 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Does finasteride/dutasteride reverse aging?

Sea_Tax6643 in Chat 45 upvotes 3 months ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Super happy, beyond my expectations. Definitely changed my life!

Jorge_luiz1989 in Progress Pictures 174 upvotes 1 year ago

A user who underwent a hair restoration procedure with 3,478 grafts by Jason Sorgi in Massachusetts, costing $8,500. The user is also using finasteride and minoxidil post-procedure, and is very satisfied with the natural-looking and dense results.

community Do you see any progress? 9 months in.

Sisques11 in Progress Pictures 79 upvotes 1 year ago

The user has been using minoxidil, dutasteride, and mesotherapy for hair loss for 9 months and recently added a derma-roller to their routine. Commenters agree there is visible progress and improvement in hair thickness.

community How many of you are on fin and how many are on dut

Monsiuercontour in Finasteride/Dutasteride 38 upvotes 3 months ago

Many people use finasteride and dutasteride for hair loss, with some switching due to cost or effectiveness. Minoxidil is also commonly used, and side effects like weaker erections or ball pain are reported by some.

community Hair transplant experience and progress

No-Beyond-1149 in Progress Pictures 90 upvotes 1 year ago

A user underwent a successful hair transplant with Dr. Linkov, receiving 2612 grafts, after stabilizing hair loss with finasteride and minoxidil. Fourteen months post-procedure, the user is extremely satisfied with the results, feeling more confident and looking younger.

community 2 years progress. Fin and min and microneedling

tonalquestions2020 in Progress Pictures 149 upvotes 11 months ago

The conversation discusses a user's two-year hair regrowth progress using finasteride, minoxidil, and microneedling. One user asks for a timeline of progress, another comments on hair length, and the original poster mentions using microneedling sporadically.

community Post Surgery Hairwash at H&W. Pre Flight.

LuckyGivrees in Transplants 58 upvotes 6 years ago

The conversation discusses the appearance of hair transplants immediately after surgery, noting that scars will be covered as hair grows. The original poster underwent both FUT and FUE procedures.

community Where to Begin with Microneedling?

HairLossJourney14 in Treatment 17 upvotes 1 year ago

User is considering microneedling to enhance hair regrowth after limited response to minoxidil and better results with finasteride and ketoconazole shampoo. Recommendations include using a 1.5mm derma roller once a week, avoiding minoxidil on microneedling days, and disinfecting the roller with isopropyl alcohol.

community I just made my own PRP - DIY PRP

idriveawhitecamry in Research/Science 550 upvotes 1 year ago

The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

community Tressless Pyrilutamide data analytics – Frustrated with lack of data, so I did something about it!

krenzx55 in Treatment 2 years ago

This user has conducted data scraping of 365 Reddit posts on the hairloss drug Pyrilutamide over the last year to analyse efficacy and side effects. The findings, which are available in a 19 page report with graphs, suggest that 22% of Pyrilutamide users experience positive results while 63% experience symptoms. A larger analytics project is proposed for other drugs with enough demand.

community Finasteride has not only helped my hairline but also the thickness of my hair and has helped it grow a lot in general over the last 6 months. Thoughts?

Nabbycankles444 in Progress Pictures 1 year ago

Finasteride helping to improve the user's hairline, thickness, and growth over the last 6 months. Other users offered their support and encouragement.

community Source for Pyrilutamide has disappeared

Bitter-Mongoose4479 in Treatment 21 upvotes 1 year ago

Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

community Update: 4 Month progress on Fin/Min plus dermaroller

TheOnlyPJizzle in Progress Pictures 559 upvotes 1 year ago

A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.

community Discussion: Evidence Refuting the "24-Hour Rule" for Minoxidil and Dermarolling

Keratin_Brotherhood in Treatment 9 upvotes 4 years ago

The 24-hour waiting period after dermarolling before applying minoxidil is unnecessary. New research supports the simultaneous application of minoxidil with microneedling for better hair growth results.

community Currently crushing 3 (5mg) tablets of fin into my topical min. Anyone do the same? If so how much do you add.

phonikos in Treatment 186 upvotes 8 months ago

The conversation discusses using crushed finasteride tablets mixed with topical minoxidil for hair loss treatment. Users share their experiences and opinions on the effectiveness and proper concentration of this method.

community 13 Month Results (Topical Fin and Min)

_Mad_Jack_ in Progress Pictures 215 upvotes 1 year ago

A user sharing their 13-month hair regrowth results using topical finasteride and minoxidil. They noticed improvement around 4 months in, and despite initial confusion due to photo order, most users acknowledged the positive change.

community Anecdotal, but: Adding RU58841 has stopped my Dutasteride shed

RightCut4940 in Finasteride/Dutasteride 21 upvotes 1 year ago

Adding RU58841 to Dutasteride treatment helped reduce hair shedding significantly for several users. Some reported no change with RU58841, while others experienced a dramatic decrease in shedding and increased hair density.

community Half a year finasteride pill a day and minoxidil once a day and dermacollar once a week

gai6989 in Progress Pictures 250 upvotes 10 months ago

The user has been taking a daily finasteride pill, applying minoxidil once a day, and using a dermaroller once a week for six months to treat hair loss, showing progress with their treatment. Some users discussed side effects like testicular discomfort with finasteride, which may subside over time.

community Probably progress in about 4 months

mlotus141 in Progress Pictures 47 upvotes 11 months ago

The user started using minoxidil and finasteride for hair loss but stopped minoxidil due to scalp issues and tinnitus. They experienced testicular pain, shedding, and side effects like itchy chest and watery sperm, but noticed considerable hair regrowth except at the temples.