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    GlossaryPain Mediator (pain modulator)

    substance that transmits and modulates pain signals in the body

    A pain mediator, also known as a pain signaling molecule, is a substance in the body that plays a crucial role in the transmission and modulation of pain signals. These molecules, such as prostaglandins, bradykinin, and substance P, are released in response to injury or inflammation and interact with nerve receptors to amplify the sensation of pain. Understanding pain mediators is essential for developing effective pain management therapies.

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      community Help! Gyne after 20 years of taking Dut

      in Finasteride/Dutasteride  39 upvotes 1 year ago
      A 43-year-old experienced gynecomastia after 20 years of taking dutasteride and 7.5mg oral minoxidil. Suggestions include consulting an endocrinologist, checking hormones, and considering Nolvadex or DIM supplements.

      community The hardest hair protocol ever!

      in Research/Science  10 upvotes 3 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

      community So we’re just ok with taking a research chemical now?

      in Treatment  176 upvotes 5 years ago
      The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.