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research The Organizer and Beyond

9 citations , July 2001 in “Cell”

This review discusses historical and recent advances in understanding the embryonic organizer's role in patterning during development, including molecular pathways and future research challenges, but reports no new experimental data.

research Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers

4 citations , October 2017 in “Advances in tissue engineering & regenerative medicine”

In this study, a bioengineered construct using a biodegradable polycaprolactone mat cocultured with human keratinocyte and rabbit dermal fibroblast cells demonstrated potential as a tissue-engineered skin substitute, showing good cell adhesion and growth.

Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

research 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling

April 2023 in “Journal of Investigative Dermatology”

In this study using a mouse model of Pemphigus vulgaris, researchers found that loss of desmoglein 3 adhesion in hair follicle stem cells triggers a regenerative program restoring stem cell function, requiring Hedgehog pathway suppression.

research RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

42 citations , December 2011 in “The journal of immunology/The Journal of immunology”

In this study, transgenic mice with Rank expression in hair follicles showed excessive lymph node growth, which could be normalized by neutralizing the overproduced RANKL, underscoring its role in immune system regulation.

research Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte–Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds

July 2026 in “Acta Biomaterialia”

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

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community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community 70ish days on oral fin and min

in Is this regrowth? 19 upvotes 4 months ago

The conversation discusses hair regrowth progress after approximately 70 days of using oral finasteride and minoxidil. Users suggest waiting longer, around six months, to see more noticeable results.

community 1 year of 1,25 mg oral FIN - Progress

in Is this regrowth? 172 upvotes 1 year ago

A 23-year-old experiencing hair thinning has seen noticeable improvement after using 1.25 mg oral finasteride for over a year and recently starting 2.5 mg oral minoxidil, along with ketoconazole shampoo. They are considering a hair transplant in the future and have not experienced any side effects from the medication.

community When could we expect pp405 to hit the market?

31 upvotes 1 year ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 10 months ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

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learn Beta Polypeptide

learn Epidermal Growth Factor

learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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