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research Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia
Verteporfin reduces growth and stem cell traits in rat hair follicle cells by blocking the Hippo pathway.
research Minoxidil suppressed cerebral ischemic injury by direct effect on neural tissues but not by reducing blood pressure.
Minoxidil protects brain tissue directly, not by lowering blood pressure.
research A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells
research Effects of Solvent System and Storage Condition on Chemical Stability of 5(alpha)-Reductase Inhibitor Compounds in Tectona grandis L.f. Leaf Extracts
Store Tectona grandis leaf extracts in slightly acidic, light-protected conditions for best stability.
research A proposed etiopathology of persistent dysfunctions emerging from use and discontinuation of 5-alpha reductase inhibitors: sequelae of drug-mediated microvasculopathy
The document suggests that drugs for prostate issues might cause lasting sexual, mental, and physical health problems due to blood vessel damage in the penis.
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5 / 108 resultscommunity Reducing Fibrosis in Hair Loss: Topical Pirfenidone
Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.
community Finasteride does deplete important nuero-active steroids
Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.
community Fresh off the press: Dutasteride may cause chronic infertility
Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.
community Ketoconazole shampoo has worked great for me. Those looking to take preventative measures should consider it.
Ketoconazole shampoo helps reduce hair shedding and improve thickness for some, but can cause dryness or irritation. Its effectiveness compared to finasteride or minoxidil varies among users.
community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle
The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.