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Glossary Neurogenic Inflammation

inflammation triggered by nerve-released chemicals causing redness and pain

Neurogenic inflammation is a type of inflammation triggered by the nervous system. It occurs when nerve fibers release certain chemicals, like substance P and calcitonin gene-related peptide (CGRP), which cause blood vessels to expand and immune cells to become activated, leading to redness, swelling, and pain. This process is often involved in conditions like migraines, asthma, and some skin disorders.

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Research

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research Neurogenic skin inflammation in stress‐triggered inhibition of hair growth in mice is promoted via nerve growth factor‐dependent pathways

September 2004 in “Experimental Dermatology”

In this study, neutralizing nerve growth factor reduced stress-triggered hair loss in mice, suggesting that nerve-immune system interactions and neurogenic inflammation contribute to this condition.

research LB1059 Neuromediators associated with neurogenic skin inflammation promote M2 differentiation of macrophages in human skin ex vivo

July 2024 in “Journal of Investigative Dermatology”

Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.

research Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link

15 citations , January 2015 in “Skin Appendage Disorders”

This report discusses a series of patients with frontal fibrosing alopecia experiencing increased scalp sweating, which the authors hypothesize may be related to local skin inflammation affecting sweat gland activity.

research Neuroimmunoendocrine circuitry of the ‘brain-skin connection’

293 citations , November 2005 in “Trends in Immunology”

This study indicates that stress in mice recruits specific neuroimmunoendocrine elements, leading to neurogenic skin inflammation that inhibits hair growth and highlights the skin's role in stress response research.

research Is there a ‘gut–brain–skin axis’?

185 citations , January 2010 in “Experimental Dermatology”

This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

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