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Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

This review examined and discussed the role of dermis-derived factors in the regulation of melanogenesis, noting their significance in both normal and abnormal mammalian skin conditions, suggesting an underexplored area of study compared to dermal and epidermal influences.

Increased Expression of Nerve Growth Factor and Neurokinin-1 Alarm the Hair Loss in Females with Trichodynia

research Increased expression of nerve growth factor and neurokinin-1 alarm the hair loss in female with trichodynia

March 2012 in “Journal of The American Academy of Dermatology”

Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.

research Secretome of Mesenchymal Stromal Cells as a Possible Innovative Therapeutic Tool in Facial Nerve Injury Treatment

2 citations , January 2023 in “BioMed Research International”

This review discusses the potential of mesenchymal stromal cell secretome therapies for facial nerve palsy, emphasizing their standardization advantages over cell transplantation, but provides no new clinical results.

research Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

108 citations , July 2004 in “American Journal of Pathology”

This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.

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community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community What can be the real reason of Finasteride SE ?

18 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community How come some guys are half bald yet their hair is so healthy?

in Finasteride/Dutasteride 62 upvotes 1 year ago

A 22-year-old male experiencing diffuse thinning and frizzy hair has been using finasteride for nine months and is seeking advice on improving hair quality. Suggestions include using conditioners, biotin, rosemary oil, and addressing scalp conditions like seborrheic dermatitis or psoriasis, while finasteride may help reverse miniaturization and improve hair health.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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