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research Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis

4 citations , April 2017 in “F1000Research”

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

research Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis.

1 citations , March 2018 in “F1000Research”

This study found that diazepam has an exaggerated effect on GABAergic inhibitory tone in diabetic neuropathy mouse models, likely due to upregulated neurosteroidogenic enzymes responding to mitochondrial dysfunction.

research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

53 citations , October 2014 in “Free radical biology & medicine”

This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.

research OsUEV1B, an Ubc enzyme variant protein, is required for phosphate homeostasis in rice

4 citations , February 2021 in “Plant journal”

This study found that the protein OsUEV1B is essential for maintaining phosphate balance in rice, with Pi deficiency leading to its inhibition and causing overaccumulation of phosphate in mutants.

research The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications

January 2023 in “Postępy Dermatologii i Alergologii”

This review provides an overview of azelaic acid's dermatological uses, mechanisms, and its potential in skin cancer treatment, but reports no new clinical results.

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community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community PP405 Identity Research

in Research 292 upvotes 1 year ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community South Korean Red Light Therapy Study

41 upvotes 7 months ago

Korean scientists developed a red light therapy that reduces a hair loss marker by 92%. Users discussed the benefits and drawbacks of natural sunlight versus red light caps for hair health, with some suggesting supplements for vitamin D.

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