October 2023 in “Journal of the Endocrine Society” In this study, distinct androgen excess subtypes were identified in women with PCOS, with the adrenal androgen excess cluster showing significantly higher rates of insulin resistance and type 2 diabetes, suggesting 11-oxygenated androgens as potential drivers of metabolic risk.
23 citations
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February 2020 in “PLOS genetics” This study found that biallelic LSS mutations lead to congenital hypotrichosis and cataracts, with each tissue-specific loss of function observed in mouse models.
91 citations
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July 2022 in “Frontiers in Endocrinology” This study reported that Chinese women with PCOS exhibited diverse lipid profiles based on different characteristics, which may help understand their increased risk of cardiovascular disease.
39 citations
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April 2007 in “Therapeutic Drug Monitoring” This study found that finasteride significantly alters urinary steroid profiles, complicating the detection of steroid abuse in doping-control analysis by potentially causing false-negative results.
32 citations
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April 2016 in “Journal of Obstetrics and Gynaecology Research” This study found that women with polycystic ovary syndrome phenotypes A and B had the highest prevalence of metabolic syndrome, and that the visceral adiposity index may help predict metabolic risk.