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research Penetration of drugs through skin, a complex rate-controlling membrane

211 citations , June 2012

This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.

research Alkyl shikimates promote proliferation of human dermal fibroblasts and exhibit structure–activity relationships

June 2026 in “Scientific Reports”

This study found that alkyl shikimates with different alkyl group structures can increase or decrease fibroblast proliferation depending on concentration and alkyl chain length, with some variants showing cytotoxic effects due to their hydrophobicity and cell membrane permeability.

research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting

76 citations , June 2015 in “Journal of biomedical science”

This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.

research A mechanism for topical cutaneous calcinosis

2 citations , December 1973 in “Calcified tissue research”

This study proposed a hypothesis for cutaneous calcinosis, suggesting that feeding DHT and subsequent epilation lead to ATP release and calcium orthophosphate formation, initiating calcification in rats.

research Ethosome as a potential transdermal drug delivery system

1 citations , January 2023 in “Journal of pharmaceutical and biological sciences”

This review examines ethosomal structures and their mechanisms as skin delivery systems, outlining preparation methods and applications but presents no new experimental findings.

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community Why can’t we just do another creatine study?

153 upvotes 1 year ago

Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Being Safe on Oral Minoxidil: tl;dr on the literature.

51 upvotes 1 year ago

Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

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