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May 2010 in “Chinese journal of plastic surgery”
This study found higher expression of melatonin receptors in fibroblasts of human hypertrophic scars compared to normal skin, suggesting a possible link to scar development.
Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.
The conversation discusses the idea of creating finasteride gummies for hair loss treatment, with some users expressing skepticism about their effectiveness compared to pills. Concerns include the potential for reduced drug delivery in gummy form and the risk of children mistaking them for candy.
Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.
A user experienced hair thinning after using tamoxifen and bupropion and is now using topical dutasteride, alfatradiol, melatonin, adenosine, and specific shampoos for improvement. They are considering using steroids and are seeking advice on whether combining oral dutasteride with TRT/PEDs would affect hair health, with mixed opinions on the impact of testosterone and DHT on hair loss.
A user shared an extensive hair loss treatment regimen including dutasteride, minoxidil, tadalafil, RU58841, microneedling, and various topical and oral supplements. Responses varied, with some suggesting the regimen is excessive and others offering additional advice or expressing skepticism about its practicality and effectiveness.
Hormone that regulates sleep, sold as a supplement
Is melatonin better as a supplement or applied to the scalp?No study has compared oral and topical melatonin head to head. Topical melatonin has one small placebo-controlled pilot trial in 40 women plus a set of mostly uncontrolled studies of a cosmetic solution; oral melatonin has no published hair-loss trial at all.
Melatonin: Does it work the same for men and women?No trial has compared melatonin's effect on hair in men versus women. The only placebo-controlled scalp study enrolled 40 women, and the single reported sex difference — shedding fell in women but not men — comes from one uncontrolled 60-person observation, so any difference is unestablished.