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research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

This phase II trial found that BI 2536 demonstrated limited antitumor activity across five solid tumor types, with no confirmed objective responses observed.

research Characteristics and survival outcomes of untreated, resectable stage I–III melanoma patients in Serbia

January 2026 in “EJC Skin Cancer”

In this study, researchers detailed the sociodemographic, clinicopathological traits, and survival outcomes of untreated, resectable stage I–III melanoma patients in Serbia, focusing on recurrence rates and survival metrics segmented by AJCC sub-stage.

research Anais do II Congresso Nacional Acadêmico de Dermatologia

January 2022

This article discusses the organizational aspects of the II National Academic Congress of Dermatology in Brazil and reports no new research findings.

research Cult of the Body Beautiful: At What Cost?

2 citations , September 2012 in “Actas Dermo-Sifiliográficas”

This article discusses the modern societal obsession with body perfection and its impact on body dissatisfaction, escalating demand for aesthetic techniques, and advertising, without reporting new research findings.

research Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation

1 citations , January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study developed a mouse model to mimic PHGDH gene copy number gain, finding that increased PHGDH expression leads to abnormal melanin production, which may offer insights into its role in melanoma.

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community Using RU-58841 to Reverse Hair Loss and Balding — My Results, Review, and Where I Buy My RU-58841

45 upvotes 7 years ago

RU58841 is discussed as a hair loss treatment, with concerns about potential heart risks and systemic side effects. Some users suggest trying FDA-approved treatments like finasteride first, while others debate the safety and cost-effectiveness of RU58841.

community Are these new hair loss treatments ever gonna release?

43 upvotes 5 months ago

Hair loss treatments like Breezula and PP405 are delayed, with approvals taking years, while existing treatments like minoxidil and finasteride remain popular. New treatments like Clascoterone and Veradermics are in trials, but high costs and lengthy approval processes slow their release.

community Results from 272 diode Red Light Therapy hat exclusively.

254 upvotes 8 months ago

A user reported noticeable hair regrowth using a 272 diode red light therapy hat over 11 months without Minoxidil or Finasteride. Opinions vary on its effectiveness compared to traditional treatments, with some suggesting combining therapies for better results.

community Testosterone and hair loss seeming irrelevance

82 upvotes 3 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

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