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research The Interaction of Hair Fibers with Alkali Bromide Solutions

12 citations , October 1954 in “Textile Research Journal”

This study found that alkali bromide solutions are absorbed into hair depending on salt activity, and the presence of the salt increases water absorption compared to normal conditions.

research Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®)

2 citations , December 2021 in “BMC veterinary research”

This study found that long-term use of difluprednate ophthalmic emulsion in dogs can lead to HPA axis suppression and potentially cause iatrogenic hyperadrenocorticism, with localized alopecia suspected due to dermal absorption.

research Root hair growth: it's a one way street

56 citations , February 2015 in “F1000 prime reports”

This review outlines the factors controlling root hair growth in plants, emphasizing the coordinated roles of cellular and extracellular components, without reporting new experimental results.

research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

research Advances in the Chemical Structure of the Hair Surface, Surface Forces and Interactions

1 citations , March 2021

This chapter provides an overview of the complex chemical and physical structure of the hair surface, detailing how factors like ethnicity, environmental stress, and cosmetic treatments can alter its properties and influence the adhesion of hair care products.

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community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 11 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Has any data on systemic absorption of pyrilutamide been published?

1 upvotes 4 months ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

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