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Concentrate of your own blood platelets, injected into the scalp

What exactly is platelet-rich plasma (PRP), and why is it popular for treating hair loss? PRP injects a concentrate of your own blood platelets into the scalp. Small trials show modest density gains, and it is used off-label.
How many PRP (platelet-rich plasma) sessions are used, and when might results show? There is no standard schedule. Trials usually gave about three monthly sessions and measured results after 3 to 6 months.
Is Platelet-Rich Plasma more effective when combined with topical treatments or supplements? Small, mostly high-risk-of-bias trials suggest adding PRP to minoxidil may improve hair density; the evidence is low to very low certainty, and no trial has tested PRP with supplements.
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Research

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research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

28 citations , September 2020 in “International Journal of Molecular Sciences”

This study concluded that leucocyte-rich PRP has a continuous stimulatory effect on human fibroblast cells, enhancing their proliferation, migration, and impacting gene expression of the extracellular matrix and adhesion molecules.

research The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

October 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study evaluated the effects of platelet-rich plasma (PRP) on endometriosis but found no statistically significant overall difference in endometriotic foci size reduction between treated and control groups.

research 556 Safety and efficacy of leukocyte-rich platelet-rich plasma in the treatment of cicatricial alopecia

June 2020 in “Journal of Investigative Dermatology”

This study found that leukocyte-rich platelet-rich plasma appeared safe and may offer some benefits to patients with scarring alopecia, though further research is needed due to the small sample size.

research Injectable Platelet-, Leukocyte-, and Fibrin-Rich Plasma (iL-PRF) in the Management of Androgenetic Alopecia

16 citations , July 2018 in “Dermatologic Surgery”

In this study, iL-PRF injections produced significantly better clinical scores for androgenetic alopecia patients compared to controls, especially in those with more severe baseline conditions.

research Novel method for preparation of autologous leucocyte rich platelet rich plasma (L-PRP) under closed system and assessment of its clinical efficacy in androgenic alopecia- a retrospective cohort study

January 2025 in “Journal of Plastic Reconstructive & Aesthetic Surgery”

Two L-PRP treatments improve hair density in mild to moderate alopecia.

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research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

research The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

research 556 Safety and efficacy of leukocyte-rich platelet-rich plasma in the treatment of cicatricial alopecia

research Injectable Platelet-, Leukocyte-, and Fibrin-Rich Plasma (iL-PRF) in the Management of Androgenetic Alopecia

research Novel method for preparation of autologous leucocyte rich platelet rich plasma (L-PRP) under closed system and assessment of its clinical efficacy in androgenic alopecia- a retrospective cohort study

Clinics

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community Do Platelet-rich plasma, PRP work?

community Thoughts on platelet-rich plasma therapy

community Microneedling versus Platelet-Rich Plasma

Experts

Dr. Richa Sanmukhani, MD

Dr. Richie-Ann Rodriguez

Rich Ehrlichman, MD, Assistant Professor of Surgery, Harvard Medical School, Assistant Surgeon, Massachusetts General Hospital