The Effects of Leukocyte- and Platelet-Rich Plasma (L-PRP) and Pure Platelet-Rich Plasma (P-PRP) on a Rat Endometriosis Model

    October 2019 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Ali Doğukan Anğın, İsmet Gün, Önder Sakin, Muzaffer Seyhan Çıkman, Zehra Meltem Pirioğlu, Ahmet Kale, Kayhan Başak, Pınar Kaygın, Serpil Oğuztüzün
    TLDR L-PRP and P-PRP reduced endometriosis in rats, but not significantly more than saline.
    The study aimed to investigate the effects of platelet-rich plasma (PRP) derivatives on endometriosis using a rat model. It involved 33 rats divided into groups receiving saline, leukocyte- and platelet-rich plasma (L-PRP), and pure platelet-rich plasma (P-PRP). The results showed that while there was a significant reduction in the volume of endometriotic foci within each group by the end of the experiment, there was no statistically significant difference between the groups in terms of volume reduction or histopathological and immunohistochemical assessments. Although L-PRP and P-PRP led to more reduction in endometriosis foci, they did not result in statistically significant differences compared to the control.
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