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    Glossary Androgen Receptor Signaling

    hormones like testosterone bind to receptors, influencing gene expression

    Androgen Receptor Signaling, also known as AR signaling, is a biological pathway where androgens (male hormones like testosterone) bind to androgen receptors in cells. This binding activates the receptors, which then influence the expression of specific genes, affecting various bodily functions such as hair growth, muscle development, and reproductive processes. In the context of hair, AR signaling can play a role in conditions like androgenetic alopecia (pattern hair loss).

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    1. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    2. Neem Oil Oil from the neem tree, used in traditional remedies
    3. GT20029 Experimental topical drug designed to break down androgen receptors
    4. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    5. Pyrilutamide Experimental topical anti-androgen, also known as KX-826