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Glossary Keratin 1

protein providing structural support in skin cells

Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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Research

5 / 1000+ results

research Characterization of Bsk mice: I. The Bsk mutation does not involve a recombination of cornea-specific keratin 12 and skin-specific hair keratin genes.

4 citations , May 1998 in “PubMed”

This study found that the Bsk phenotype in mice did not result from a recombination event between specific keratin genes, leaving the gene linked to this mutation unidentified.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure

51 citations , January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.

research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

44 citations , August 1990 in “PubMed”

This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.

research Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter

30 citations , March 2019 in “Archives animal breeding/Archiv für Tierzucht”

In this study, variation in the KRTAP15-1 gene in goats was linked to changes in cashmere fibre diameter, with specific variants showing dominant or recessive effects.

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Community Join

5 / 141 results

community 35M, been on 1 mg Fin 12 years/5mg Oral Min 3 years no side effects. Considering a conservative HT. Thoughts?

50 upvotes 1 month ago

A 35-year-old man has been using finasteride for 12 years and oral minoxidil for 3 years without side effects, maintaining a stable hairline. He is considering a conservative hair transplant to slightly lower and reinforce his hairline, with a preference for North American surgeons.

community Is it safe to get keratin treatment on transplanted hair?

2 upvotes 2 years ago

A user with frizzy transplanted hair is considering a keratin treatment after 10 months and is concerned about its safety and potential to accelerate hair loss or cause telogen effluvium. They are seeking advice on whether it is safe to proceed with the treatment.

community 2019 vs 2022 vs 2026: 1mg oral fin, 0.1% fin + 7% minox topical daily for 2-2.5 years, nizoral 2-3 times weekly, random 0.5-2mm microneedling every 2-3 months

74 upvotes 3 months ago

The user experienced significant hair regrowth using a regimen of 1mg oral finasteride, 0.1% finasteride and 7% minoxidil topical daily, along with nizoral and microneedling. They regained all lost hair and more, achieving a Norwood 1.5 hairline with improved hair and scalp texture.

community Why isn't this a thing? Why isn't it even talked here?

7 upvotes 5 years ago

The conversation discusses the effectiveness of AMSbzs supplements in significantly increasing hair count, weight, and keratin content. The user questions why this treatment isn't more widely known despite its impressive results.

community Additional supplements / peptides to maximize finasteride benefit

in Research/Science 3 upvotes 3 months ago

The user is using finasteride, HGH, GHK-CU, BPC-157, KPV, biotin/collagen/keratin vitamins, ketoconazole shampoo, and low-dose naltrexone to address hair loss, avoiding minoxidil due to past shedding experiences. Adenosine is discussed as a potential alternative to minoxidil, though it is noted to be expensive and hard to find.

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Learn

5 / 801 results

learn Overview

learn Keratin

What role does keratin play in strengthening weak or thinning hair? Keratin strengthens hair by forming protective structures that prevent breakage and thinning.
Are keratin treatments good for people with alopecia, or do they only improve the hair’s appearance? Keratin treatments improve hair appearance but do not address alopecia or stimulate growth.
Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos mainly coats the hair rather than being absorbed.
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learn Hydrolyzed Keratin

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learn PEG-12 Dimethicone

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Clinics

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