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Glossary Interleukin-1 alpha

promotes inflammation and influences hair follicle biology

Interleukin-1 alpha (IL-1α) is a type of protein known as a cytokine, which plays a crucial role in the body's immune response by promoting inflammation. It is involved in various cellular activities, including cell proliferation, differentiation, and apoptosis. In the context of hair and alopecia, IL-1α can influence hair follicle biology and has been implicated in inflammatory conditions that may lead to hair loss.

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Research

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research Minoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells

16 citations , January 2018 in “International Journal of Trichology”

In this study, minoxidil significantly downregulated interleukin-1 alpha expression in human keratinocyte cells, suggesting an anti-inflammatory effect that may be a mechanism of action in treating alopecia.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.

research IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures.

30 citations , August 1993 in “PubMed”

This study found that IL-1 alpha inhibits the growth of cultured human hair follicles and hair fibers, suggesting a potential role in inflammatory hair loss conditions like alopecia areata.

research Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin

1 citations , December 2012 in “Papers on Anthropology”

This study found that psoriatic skin lesions commonly express the cytokines IL-6, IL-8, and TNF-alpha along with a moderate presence of the antimicrobial protein defensin.

research Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata

1 citations , July 2012 in “Nasza Dermatologia Online”

This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.

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Community Join

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community UPDATE: The theory that explains everything. Please help me make this big!

447 upvotes 5 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The 2026 Breakthrough Pipeline: Top 5 Mind-Changing Hair Loss Treatments To Watch

1 week ago

New hair loss treatments include lab-grown hair cloning, scarless healing with verteporfin, GT20029 for receptor degradation, JAK inhibitors for follicle activation, and dermal papilla stem cell exosomes. These aim to regenerate hair rather than just slow hair loss.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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